Endocrine Abstracts

Introduction: Distinguishing arginine vasopressin deficiency (AVD) from primary polydipsia (PP) can be challenging in clinical practice. Copeptin is produced in equimolar amount to AV and is considered diagnostic biomarker to establish the diagnosis of AVD with and without provocative testing.Methods: Patients referred with polydipsia, hypotonic polyuria (>3L/day) and normonatraemia had overnight fasting plasma copep...

Background: Cranial Diabetes insipidus (CDI) is a rare condition but is potentially life-threatening if there is a delay or omission of desmopressin. Recent patient safety alerts highlighted the need to raise awareness to avoid mortality and morbidity. The baseline knowledge of the health care professional (HCPs) is very important to avoid deleterious outcomes.Aim: Qualitative survey to determine the baseline knowledge a...

Introduction: The response to SARS-CoV-2 lead to interventions to mitigate the pandemic. We retrospectively analysed the effect of changes on key NET services. These included: change in clinic media, absolute change in numbers for endoscopy and bronchoscopy, nuclear imaging, SSA administration and PRRT numbers compared with 2019.Method: The NET database was analysed. Endoscopy rates on a monthly basis were reviewed. Two bespoke postal patient surveys wer...

Introduction: Pulmonary neuroendocrine tumours (pulNETs) histologically encompass: small cell, large cell, typical (TC) and atypical carcinoid (AC). Diffuse idiopathic pulmonary neuroendocrine hyperplasia (DIPNECH) is a very rare condition but potentially progress to pulNET and is associated with MEN. Advances in treatment have modified management, and there have been recommendations to use Ki67 for grading. However there is a paucity of randomized studies.<p class="abstex...

Introduction: Carcinoid heart disease can occur in up to 20 % of patients with carcinoid syndrome. It is a regarded as a rare complication and associated with high morbidity and mortality as a sequela of vasoactive peptides resulting in plaque formation on the valve leaflets classically tricuspid and pulmonary valves and causing right heart failure. Definitive treatment is surgical valve replacement, but percutaneous valve management is an attractive alternative for those deem...

Introduction: The COVID-19 pandemic has affected patient care and experience. We assessed the evolution of NET patient perceptions during and peri-pandemic via a bespoke patient satisfaction survey.Methods: In February 2022, questionnaires with a pre-paid return envelope were posted out to 87 randomly selected NET patients, treated between January and December 2021. This consisted of 29 questions covering: initial contact, physician care and support, ill...

Introduction: Established guidelines recommend carefully selected patients with Carcinoid Heart Disease (CHD) may undergo surgical valve replacement as definitive management. Right sided heart valve involvement is classical, occurring as result of plaque deposition on valve leaflets as a consequence of vasoactive peptides secreted by the NET because of carcinoid syndrome. Tricuspid and Pulmonary valve involvement leads to right heart failure (RHF) increasing mortality and morb...

Case history: A 59-year-old male presented to gastroenterology with a two years of high volume persistent watery diarrhoea. He gave a past medical history of poorly controlled, insulin treated diabetes mellitus present for 8 years. He reported abdominal pain and diarrhoea that persisted despite fasting. A colonoscopy with biopsy were reported as normal. Diarrhoea, malaise, fatigue and weight loss persisted.Investigations: Stool culture and faecal elastas...

Pancreatic neuroendocrine tumours are rare with an incidence of 5 per million. Of these tumours, 75% maybe hormonally functioning. They carry a better prognosis than adenocarcinoma of the pancreas. Parathyroid Hormone related peptide hypersecretion in PNETs is uncommon and is solely associated with metastatic PNETs. 31 cases are reported of PTH-rPoma in the literature. Here we describe a novel case presenting with cough. A previously well 56-year-old female presented to the ac...

Introduction: Pregnancy in women with pre-existing Type 1 diabetes (T1DM) is known to carry a 3–5 times increased frequency of severe hypoglycaemia (SH) in the first compared to the third trimester. The main predictors are: pre-gestational SH, HbA1C <6.5%/48 mmol/mol, duration of diabetes and higher total daily insulin doses. Freestyle Libre or flash monitoring utilizes a 14 day tiny glucose sensor which is applied to the back of the arm and scanned with a reader, to ...